资源类型

期刊论文 98

年份

2023 16

2022 10

2021 10

2020 5

2019 6

2018 12

2017 3

2016 8

2015 7

2014 1

2013 1

2012 3

2011 3

2010 4

2009 1

2007 1

2006 1

2003 1

2000 1

展开 ︾

关键词

CO2泡沫 1

CPU-GPU异构；多核；共享内存；访存调度 1

一维应力波 1

三维布局；势能曲面变平；布局优化；性能约束 1

上下行解耦；用户接入；资源划分；异构蜂窝网络；联合博弈 1

不确定威胁 1

什刹前海 1

传播与演化 1

传输安全 1

催化膜反应器 1

刨煤机成套装备 1

动态异构冗余架构 1

协同；同宿；异构计算；微服务；资源调度技术 1

双抗原 1

园林学 1

城市化进程 1

城市园林 1

城市学 1

城市景观水体 1

展开 ︾

检索范围：

排序： 展示方式：

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

《化学科学与工程前沿（英文）》 2022年 第16卷 第3期   页码 333-344 doi: 10.1007/s11705-021-2059-5

摘要： Compared to conventional hyperthermia that is limited by low selectivity and severe side effects, nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer treatment. Another major advance is the observation of immunological responses associated with nano-enabled hyperthermia, which introduces a new avenue, allowing a potential paradigm shift from the acutely effective and cytotoxicity-centric response to the next-phase discovery, i.e., long-lasting and/or systemic anti-tumor immunity. This perspective first discusses the temperature-gradient and the spatially-structured immunological landscape in solid tumors receiving nano-enabled hyperthermia. This includes the discussion about underlying mechanism such as immunogenic cell death, which initiates a profound immunological chain reaction. In order to propagate the immune activation as a viable therapeutic principle, we further discussed the tumor type-specific complexity in the immunological tumor microenvironment, including the creative design of nano-enabled combination therapy to synergize with nano-enabled hyperthermia.

关键词： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

HTML PDF 收藏

Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

《医学前沿（英文）》 2009年 第3卷 第1期   页码 91-95 doi: 10.1007/s11684-009-0011-z

摘要： To study the efficacy of Fuganling granula (FGL, 复肝灵颗粒) in treating mouse immunological hepatic injury that was caused by Bacille Calmette Guerin (BCG) and lipopolysaccharide (LPS), a total of 60 mice were adopted, among which, 50 mice were given intraperitoneal injection with BCG and LPS to establish an immunological liver injury model and then were randomly divided into 5 groups (10 mice/group): 4 groups received treatment of FGL orally at the doses of 100 mg/kg (high-dosage), 50 mg/kg (middle-dosage), 25 mg/kg (low-dosage) and bifendate orally at the dose of 80 mg/kg, respectively. One group was treated with distilled water orally. The remaining 10 mice were given distilled water intraperitoneally as the normal control group. The indices of thymus, liver and spleen, and the activities of the alanine aminotransferase (ALT), aspartate aminotransferase (AST) in the serum were detected. Compared to the normal rat, the model group’s thymus index decreased significantly. The liver index and spleen index increased significantly. The activities of serum ALT and AST increased significantly (all < 0.01). Compared to the model control group, the group treated with FGL in high-dosage, middle-dosage or low-dosage can decrease the activities of ALT and AST and the group treated with FGL in high-dosage and middle-dosage can increase the thymus index significantly ( < 0.01). This experiment established the immunological liver injury model successfully and found that FGL has a remarkably protective effect on this kind of immunological hepatic injury.

关键词： Fuganling granula     immunological liver injury     bacille calmette guerin     lipopolysaccharide     mice    

HTML PDF 收藏

Emerging immunological strategies: recent advances and future directions

《医学前沿（英文）》 2021年 第15卷 第6期   页码 805-828 doi: 10.1007/s11684-021-0886-x

摘要： Immunotherapy plays a compelling role in cancer treatment and has already made remarkable progress. However, many patients receiving immune checkpoint inhibitors fail to achieve clinical benefits, and the response rates vary among tumor types. New approaches that promote anti-tumor immunity have recently been developed, such as small molecules, bispecific antibodies, chimeric antigen receptor T cell products, and cancer vaccines. Small molecule drugs include agonists and inhibitors that can reach the intracellular or extracellular targets of immune cells participating in innate or adaptive immune pathways. Bispecific antibodies, which bind two different antigens or one antigen with two different epitopes, are of great interest. Chimeric antigen receptor T cell products and cancer vaccines have also been investigated. This review explores the recent progress and challenges of different forms of immunotherapy agents and provides an insight into future immunotherapeutic strategies.

关键词： cancer immunotherapy     bispecific antibodies     small molecules     chimeric antigen receptor T therapy     cancer vaccines    

HTML PDF 收藏

The ecological system and the regionalization of landscape reconstruction in northwest of China

Peicheng LI,Guoyuan DU,Qilei LI,Jinfeng WANG,Feimin ZHENG

《农业科学与工程前沿（英文）》 2014年 第1卷 第4期   页码 291-298 doi: 10.15302/J-FASE-2014033

摘要： The northwest of China is a vast area with abundant resources and significant potential for development. However, the ecological system is extremely vulnerable to damage and must be managed carefully. Thus, the Chinese government is strengthening research on improvement and reconstruction of the ecological system and landscape in northwest of China while moving forward with large-scale development in west China. The disadvantages and vulnerabilities in the northwest area in China are presented. It is suggested that the reconstruction of landscape should be conducted by step by step regionalization across the various ecological systems in the 3.04 million km northwest area of China. The first level regionalization results of reconstruction of landscape are discussed.

关键词： reconstruction of landscape     ecological system     the northwest area of China     science and technology action    

HTML PDF 收藏

Research on a quantificational method for chromatic-light emotions of architectural wall coatings in landscape

Ting WANG, Ma JIAN, Gang LIU, Xiaoxi LIU, Mingyu ZHANG

《结构与土木工程前沿（英文）》 2010年 第4卷 第4期   页码 498-502 doi: 10.1007/s11709-010-0096-0

摘要： Research on quantificational methods for chromatic-light emotion is an effective way of finding out the laws of light cognitive impact and the solution to the problem on application of light color in landscape lighting. This paper took chromatic-light-induced-emotion towards architectural wall coatings in landscape as the research object. The methods in use were real-state simulation and laboratory quantitative study. Consequently, the study successfully extracted light emotional factors and the rule of predictability to assist landscape light professionals.

关键词： landscape illumination     architectural wall coatings     chromatic-light emotion     quantitative research    

HTML PDF 收藏

FLOWERING PLANTS AND ENTOMOPHAGOUS ARTHROPODS IN THE AGRICULTURAL LANDSCAPE: A PRACTISE-ORIENTED SUMMARY

《农业科学与工程前沿（英文）》 2022年 第9卷 第1期   页码 63-74 doi: 10.15302/J-FASE-2021427

摘要：

There is a growing demand for high-quality agricultural products and more countries have adopted landscape management by sowing flowering plants in agricultural fields as an important branch of conservation biological control. However, there has been less concern over the interactions and trade-offs between floral plants and entomophagous arthropods. This paper review progress in pollen/nectar feeding habits of entomophagous insects including parasitoids and predators which are important natural enemies of crop pests in agricultural fields. Factors that influence the preference of different guilds of natural enemies are reviewed to guide the selection of flowering plants in conservation biological control practices. Most studies find that floral resources have positive effects on both biological traits of natural enemies and their abundance and diversity, and this is believed to contribute greatly to pest control. Furthermore, the potential impacts of floral resources on crop yields are also discussed with an emphasis on a guild of entomophagous insects that provides both pest control and pollination services.

 

关键词： ecosystem services / flowering plants / natural enemies / nectar / pollen    

HTML PDF 收藏

of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial landscape

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

《环境科学与工程前沿（英文）》 2015年 第9卷 第2期   页码 269-278 doi: 10.1007/s11783-014-0672-y

摘要： Soil moisture variability in natural landscapes has been widely studied; however, less attention has been paid to its variability in the urban landscapes with respect to the possible influence of texture stratification and irrigation management. Therefore, a case study was carried out in the Beijing Olympic Forest Park to continuously monitor the soil in three typical profiles from 26 April to 11 November 2010. The texture stratification significantly affected the vertical distribution of moisture in the non-irrigated profile where moisture was mostly below field capacity. In the profile where irrigation was sufficient to maintain moisture above field capacity, gravity flow led to increased moisture with depth and thus eliminated the influence of texture. In the non-irrigated sites, the upper layer (above 80 cm) exhibited long-term moisture persistence with the time scale approximating the average rainfall interval. However, a coarse-textured layer weakened the influence of rainfall, and a fine-textured layer weakened the influence of evapotranspiration, both of which resulted in random noise-like moisture series in the deeper layers. At the irrigated site, frequent irrigation neutralized the influence of evapotranspiration in the upper layer (above 60 cm) and overshadowed the influence of rainfall in the deeper layer. As a result, the moisture level in the upper layer also behaved as a random noise-like series; whereas due to deep transpiration, the moisture of the deep layer had a persistence time-scale longer than a month, consistent with characteristic time-scales found for deep transpiration.

关键词： moisture vertical distribution     moisture temporal variation     texture stratification     irrigation     meteorological forcing     urban landscape    

HTML PDF 收藏

Autoimmune hepatitis

null

《医学前沿（英文）》 2015年 第9卷 第2期   页码 187-219 doi: 10.1007/s11684-015-0386-y

摘要：

Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specific autoantigens. It is characterized by female predilection, elevated aminotransferase levels, autoantibodies, increased γ-globulin or IgG levels and biopsy evidence of interface hepatitis. It is currently divided into types 1 and 2, based on expression of autoantibodies. Autoantigenic epitopes have been identified only for the less frequent type 2. Although autoimmune hepatitis occurs in childhood, this review focuses on disease in adults. In the absence of pathognomonic biomarkers, diagnosis requires consideration of clinical, biochemical, serological and histological features, which have been codified into validated diagnostic scoring systems. Since many features also occur in other chronic liver diseases, these scoring systems aid evaluation of the differential diagnosis. New practice guidelines have redefined criteria for remission to include complete biochemical and histological normalization on immunosuppressive therapy. Immunosuppression is most often successful using prednisone or prednisolone and azathioprine; however, the combination of budesonide and azathioprine for non-cirrhotic patients offers distinct advantages. Patients failing standard immunosuppression are candidates for alternative immunosuppressive regimens, yet none of the options has been studied in a randomized, controlled trial. Overlap syndromes with either primary sclerosing cholangitis or primary biliary cirrhosis occur in a minority. Liver transplantation represents a life-saving option for patients presenting with acute liver failure, severely decompensated cirrhosis or hepatocellular carcinoma. Transplant recipients are at risk for recurrent autoimmune hepatitis in the allograft, and de novo disease may occur in patients transplanted for other indications. Patients transplanted for AIH are also at risk for recurrent or de novo inflammatory bowel disease. Progress in our understanding of the immunopathogenesis should lead to identification of specific diagnostic and prognostic biomarkers and new therapeutic strategies.

关键词： autoimmune hepatitis     autoantibodies     diagnosis     immunological diseases     drug-induced liver injury     therapy     immunosuppression     outcomes     hepatocellular carcinoma     liver transplantation    

HTML PDF 收藏

Computational design of heterogeneous catalysts and gas separation materials for advanced chemical processing

Huaiwei Shi, Teng Zhou

《化学科学与工程前沿（英文）》 2021年 第15卷 第1期   页码 49-59 doi: 10.1007/s11705-020-1959-0

摘要： Functional materials are widely used in chemical industry in order to reduce the process cost while simultaneously increase the product quality. Considering their significant effects, systematic methods for the optimal selection and design of materials are essential. The conventional synthesis-and-test method for materials development is inefficient and costly. Additionally, the performance of the resulting materials is usually limited by the designer’s expertise. During the past few decades, computational methods have been significantly developed and they now become a very important tool for the optimal design of functional materials for various chemical processes. This article selectively focuses on two important process functional materials, namely heterogeneous catalyst and gas separation agent. Theoretical methods and representative works for computational screening and design of these materials are reviewed.

关键词： heterogeneous catalyst     gas separation     solvent     porous adsorbent     material screening and design    

HTML PDF 收藏

nitrogen/phosphorus concentration and hydraulic retention time for bloom control in reclaimed water landscape

《环境科学与工程前沿（英文）》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1564-1

摘要：

● A new model for bloom control in open land scape water was constructed.

关键词： Reclaimed water landscape     Algal bloom     Nitrogen and phosphorus     Hydraulic retention time     Threshold     Control model    

HTML PDF 收藏

Application of heterogeneous catalysis to biodiesel synthesis using microalgae oil

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1343-9

摘要：

• Microalgae oil application for biodiesel synthesis is discussed.

关键词： Biodiesel     Heterogeneous catalysis     Transesterification     Microalgae oil    

HTML PDF 收藏

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

《医学前沿（英文）》   页码 889-906 doi: 10.1007/s11684-023-0994-x

摘要： Primary central nervous system lymphoma (PCNSL) is an uncommon non-Hodgkin’s lymphoma with poor prognosis. This study aimed to depict the genetic landscape of Chinese PCNSLs. Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics and clinicopathologic features were also analyzed. Structural variations were identified in all patients with a mean of 349, which did not significantly influence prognosis. Copy loss occurred in all samples, while gains were detected in 77.9% of the samples. The high level of copy number variations was significantly associated with poor progression-free survival (PFS) and overall survival (OS). A total of 263 genes mutated in coding regions were identified, including 6 newly discovered genes (ROBO2, KMT2C, CXCR4, MYOM2, BCLAF1, and NRXN3) detected in ≥ 10% of the cases. CD79B mutation was significantly associated with lower PFS, TMSB4X mutation and high expression of TMSB4X protein was associated with lower OS. A prognostic risk scoring system was also established for PCNSL, which included Karnofsky performance status and six mutated genes (BRD4, EBF1, BTG1, CCND3, STAG2, and TMSB4X). Collectively, this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs, thereby enriching the present understanding of the genetic mechanisms of PCNSL.

关键词： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation     gene mutation    

HTML PDF 收藏

以东为鉴 秀丽晚成——西部风景园林开发浅议

孟兆祯

《中国工程科学》 2000年 第2卷 第10期   页码 56-58

摘要：

首先我们要站在人类社会生产与自然环境协调的可持续发展的高度着手综合的国土规划，建立从总体到单体的规划设计科学序列。现阶段城市的本质应为人类聚居并藉以生存的生活环境。城市化进程与自然环境间并非针锋相对的破坏关系。城市形象不仅仅是建筑加道路的形象，而是以人工美入自然，将城市和建筑融汇到自然环境中的形象。我们美好的前景是将城市和建筑建在绿色环境中。风景名胜区和城市园林的建设当前仍须将保护自然资源放在首位。要创造特色，从各市的自然环境和人文脉络中捕捉城市风景园林的特色，不要盲目跟风。秀丽山川，大器晚成。扎实积累，功到必成。

关键词： 城市化进程     风景名胜区     城市园林    

HTML PDF 收藏

Social media and mobility landscape: Uncovering spatial patterns of urban human mobility with multi source

Yilan Cui, Xing Xie, Yi Liu

《环境科学与工程前沿（英文）》 2018年 第12卷 第5期 doi: 10.1007/s11783-018-1068-1

摘要：

Check-in and survey data are explored to identify personal activity-specific places.

Ways for detecting and moderating sample bias of Weibo check-in data is proposed.

A graphic representation of urban activity intensity in Beijing, China is presented.

The potential application of Weibo check-in data for urban analysis is introduced.

关键词： Social media     Human mobility     Population bias     Sample reconstruction     Data integration    

HTML PDF 收藏

Undrained seismic bearing capacity of strip footing adjacent to a heterogeneous excavation

《结构与土木工程前沿（英文）》 2023年 第17卷 第4期   页码 566-583 doi: 10.1007/s11709-023-0905-x

摘要： The analysis of the bearing capacity of strip footings sited near an excavation is critical in geotechnics. In this study, the effects of the geometrical features of the excavation and the soil strength properties on the seismic bearing capacity of a strip footing resting on an excavation were evaluated using the lower and upper bounds of the finite element limit analysis method. The effects of the setback distance ratio (L/B), excavation height ratio (H/B), soil strength heterogeneity (kB/cu), and horizontal earthquake coefficient (kh) were analyzed. Design charts and tables were produced to clarify the relationship between the undrained seismic bearing capacity and the selected parameters.

关键词： excavation     finite element limit analysis     heterogeneous soil     strip footing     undrained bearing capacity    

HTML PDF 收藏

标题 作者 时间 类型 操作

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

期刊论文

Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

期刊论文

Emerging immunological strategies: recent advances and future directions

期刊论文

The ecological system and the regionalization of landscape reconstruction in northwest of China

Peicheng LI,Guoyuan DU,Qilei LI,Jinfeng WANG,Feimin ZHENG

期刊论文

Research on a quantificational method for chromatic-light emotions of architectural wall coatings in landscape

Ting WANG, Ma JIAN, Gang LIU, Xiaoxi LIU, Mingyu ZHANG

期刊论文

FLOWERING PLANTS AND ENTOMOPHAGOUS ARTHROPODS IN THE AGRICULTURAL LANDSCAPE: A PRACTISE-ORIENTED SUMMARY

期刊论文

of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial landscape

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

期刊论文

Autoimmune hepatitis

null

期刊论文

Computational design of heterogeneous catalysts and gas separation materials for advanced chemical processing

Huaiwei Shi, Teng Zhou

期刊论文

nitrogen/phosphorus concentration and hydraulic retention time for bloom control in reclaimed water landscape

期刊论文

Application of heterogeneous catalysis to biodiesel synthesis using microalgae oil

期刊论文

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

期刊论文

以东为鉴 秀丽晚成——西部风景园林开发浅议

孟兆祯

期刊论文

Social media and mobility landscape: Uncovering spatial patterns of urban human mobility with multi source

Yilan Cui, Xing Xie, Yi Liu

期刊论文

Undrained seismic bearing capacity of strip footing adjacent to a heterogeneous excavation

期刊论文